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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K15
All Species:
8.79
Human Site:
T277
Identified Species:
24.17
UniProt:
Q6ZN16
Number Species:
8
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6ZN16
NP_001001671.2
1313
147437
T277
I
K
L
R
M
D
N
T
E
V
L
T
S
D
I
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
I307
I
R
Q
R
V
D
N
I
E
V
L
T
A
D
I
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
V269
L
Q
R
R
L
D
S
V
E
L
L
S
P
D
I
Dog
Lupus familis
XP_548885
1422
158482
T373
I
R
L
R
L
D
N
T
E
V
L
T
S
D
V
Cat
Felis silvestris
Mouse
Mus musculus
A2AQW0
1331
149309
I281
I
K
F
R
M
D
N
I
E
V
L
T
S
D
I
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514080
1407
157705
T363
I
K
L
R
M
D
N
T
E
V
L
T
P
D
I
Chicken
Gallus gallus
XP_419725
1260
143069
F243
H
V
R
L
H
Y
A
F
A
L
N
R
R
N
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
V293
I
Q
Q
R
L
D
N
V
E
C
L
S
A
D
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
V249
K
Q
L
K
N
D
H
V
T
D
K
P
A
I
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
58
44.2
81.6
N.A.
86
N.A.
N.A.
70.8
57.3
N.A.
54.4
N.A.
N.A.
N.A.
N.A.
45.4
Protein Similarity:
100
72.6
60.9
86.4
N.A.
90.3
N.A.
N.A.
79.4
73.5
N.A.
71.5
N.A.
N.A.
N.A.
N.A.
62.2
P-Site Identity:
100
66.6
40
80
N.A.
86.6
N.A.
N.A.
93.3
0
N.A.
46.6
N.A.
N.A.
N.A.
N.A.
13.3
P-Site Similarity:
100
86.6
80
100
N.A.
86.6
N.A.
N.A.
93.3
20
N.A.
80
N.A.
N.A.
N.A.
N.A.
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
12
0
12
0
0
0
34
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
12
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
89
0
0
0
12
0
0
0
78
0
% D
% Glu:
0
0
0
0
0
0
0
0
78
0
0
0
0
0
0
% E
% Phe:
0
0
12
0
0
0
0
12
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
12
0
0
0
12
0
12
0
0
0
0
0
0
0
0
% H
% Ile:
67
0
0
0
0
0
0
23
0
0
0
0
0
12
56
% I
% Lys:
12
34
0
12
0
0
0
0
0
0
12
0
0
0
0
% K
% Leu:
12
0
45
12
34
0
0
0
0
23
78
0
0
0
23
% L
% Met:
0
0
0
0
34
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
12
0
67
0
0
0
12
0
0
12
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
12
23
0
0
% P
% Gln:
0
34
23
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
23
23
78
0
0
0
0
0
0
0
12
12
0
0
% R
% Ser:
0
0
0
0
0
0
12
0
0
0
0
23
34
0
0
% S
% Thr:
0
0
0
0
0
0
0
34
12
0
0
56
0
0
0
% T
% Val:
0
12
0
0
12
0
0
34
0
56
0
0
0
0
23
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _